Table 2.

Antimicrobial susceptibilities of 18 MOMP variants derived from 8 original H. influenzae strains from seven patients showing decreased susceptibility to one or more of the antibiotics ampicillin, amoxicillin-clavulanic acid, cefuroxime, cefaclor, and trimethoprim-sulfamethoxazole during a 2-year follow-up study

PatientMOMP variantsaTime points (mo)Resultsb for:
AmpicillinAmox.-clav. acidCefuroximeCefaclorTrim.-sulfa
Suscept.Inh. zone (mm)Suscept.Inh. zone (mm)Suscept.Inh. zone (mm)Suscept.Inh. zone (mm)Suscept.Inh. zone (mm)
15a21S34S26S29S34S40
5b21S27S27S26S32R0
515a1S33S33S35S30S31
15b1S33S35S34S30R0
1030a2S31S28S27S27S34
30b2S26S28S25I19S34
2461a6S31S29S28S21R0
61b6S31S30S30I18R0
61c6S29S28S27S22R0
2767a1I23S26S34S21S35
67b1S24S21S30R0S42
67d7R16R16I22R0S29
68a7S32S30S30S29S36
68c7S32S32S34S30R0
2870a1R14R19S20S22S24
70b1R18R18S24I18S20
70c1R15R17S42R0R0
70e9R16R17S35S21S26
3077a1S23S23I23I19S33
77c1I20R19S25I18S33
77d1S23S23S25R0S33
77e1S23R13I21R0S32
77f1S28S24S28I18S33
77g1S24S25S29I19S30
77i3S24R18S28S20S32
77k14S23S23S28I19S32
  • a Numbers indicate distinct H. influenzae strains, and added letters indicate MOMP variants.

  • b Suscept., susceptibility of persistentH. influenzae isolates to the tested antibiotics. S, susceptible to the antibiotic tested; I, intermediate to the antibiotic tested; R, resistant to the antibiotic tested. Inh. zone, inhibition zone for the tested antibiotic. Amox.-clav. acid, amoxicillin-clavulanic acid; trim.-sulfa, trimethoprim-sulfamethoxazole.