Table 3.

Nucleotides and amino acids substitutions inCYP51A1 genes from C. albicansclinical isolates

Amino acid substitutionaMutation inCYP51A1 alleleb:
C23-1C23-2C39C33C34C82C26C27C37C40-1C40-2C43C56
V 82 VA 246 TA 246 TA 246 TA 246 T
F 105 FT 315 CT 315 CT 315 CT 315 CT 315 CT 315 CT 315 CT 315 C
D 116 E T 348 AT 348 AT 348 AT 348 AT 348 AT 348 AT 348 AT 348 A
K 119 KA 357 GA 357 GA 357 GA 357 GA 357 GA 357 GA 357 GA 357 G
K 128 T A 383 CA 383 C
G 129 A G 386 C
Y 132 H T 394 CT 394 C
S 137 SC 411 TC 411 TC 411 TC 411 TC 411 TC 411 TC 411 TC 411 T
L 220 LC 658 TC 658 TC 658 TC 658 TC 658 TC 658 TC 658 TC 658 T
E 266 Q G 796 CG 796 C
V 332 VT 996 CT 996 CT 996 CT 996 C
L 340 LA 1020 GA 1020 GA 1020 GA 1020 GA 1020 G
K 342 KA 1026 G
S 361 SA 1083 GA 1083 GA 1083 GA 1083 G
L 370 LC 1110 TC 1110 TC 1110 TC 1110 TC 1110 TC 1110 TC 1110 TC 1110 TC 1110 TC 1110 T
Y 401 YT 1203 CT 1203 CT 1203 CT 1203 CT 1203 C
S 405 F C 1214 TC 1214 TC 1214 TC 1214 TC 1214 T
P 419 PT 1257 C
D 428 DT 1284 CT 1284 CT 1284 CT 1284 C
V 437 I G 1309 A
V 456 VT 1368 AT 1368 AT 1368 AT 1368 A
G 464 S G 1390 AG 1390 AG 1390 AG 1390 A
R 467 K G 1400 AG 1400 AG 1400 A
L 480 LA 1440 GA 1440 GA 1440 GA 1440 GA 1440 GA 1440 GA 1440 GA 1440 GA 1440 G
N 490 NT 1470 CT 1470 CT 1470 CT 1470 CT 1470 CT 1470 CT 1470 CT 1470 C
  • a Boldface type indicates that the mutation at the corresponding site created a substitution.

  • b The base numbers are with respect to the first ATG codon of CYP51A1.