Table 2.

Effect of MMF on the antiherpesvirus activity of GCV, ACV, or PCV in Vero cells

VirusAntiviral agentEC50(μg/ml)a
GCV aloneACV alonePCV aloneWith MMF at 50 μg/mlWith MMF at 25 μg/mlWith MMF at 10 μg/mlWith MMF at 2.5 μg/mlWith MMF at 1.0 μg/ml
HSV-1GCV0.53 ± 0.110.021 ± 0.0110.014 ± 0.0040.016 ± 0.0060.019 ± 0.0090.022 ± 0.000
ACV2.45 ± 2.190.030 ± 0.0200.030 ± 0.0200.030 ± 0.0200.056 ± 0.0060.117 ± 0.033
PCV6.2 ± 1.540.20 ± 0.070.24 ± 0.060.25 ± 0.070.37 ± 0.170.26 ± 0.11
HSV-2GCV0.51 ± 0.380.002 ± 0.0010.006 ± 0.0030.010 ± 0.0000.010 ± 0.0020.076 ± 0.005
ACV1.30 ± 0.710.010 ± 0.0000.033 ± 0.0160.055 ± 0.0260.085 ± 0.0150.201 ± 0.011
PCV5.62 ± 1.550.008 ± 0.0010.038 ± 0.0530.040 ± 0.0160.160 ± 0.0101.18 ± 0.52
TKHSV-1GCV10.64 ± 3.730.46 ± 0.240.46 ± 0.240.43 ± 0.260.66 ± 0.330.79 ± 0.00
ACV32.49 ± 4.740.13 ± 0.030.30 ± 0.200.36 ± 0.130.50 ± 0.000.75 ± 0.25
PCV≥1001.4 ± 0.71.8 ± 0.82.1 ± 1.43.5 ± 1.64.9 ± 1.1
  • a Data are mean values for at least three separate experiments. The EC50 of MMF alone is >50 μg/ml.