Table 3.

Susceptibilities of 344 S. aureus strains with or without mutations in the grlA andgyrA genes

Codon(s)No. of strainsDrugMIC (μg/ml)
grlAgyrARange50%90%
80731CPFX6.25
LVFX1.56
DU-6859a0.2
808475CPFX12.5–80025100
LVFX3.13–5012.525
DU-6859a0.2–6.250.781.56
808835CPFX12.5–10025100
LVFX3.13–12.56.2512.5
DU-6859a0.2–0.780.390.78
8013CPFX3.13–12.512.512.5
LVFX0.39–6.253.133.13
DU-6859a0.05–0.390.20.39
8073 + 842CPFX50
LVFX12.5
DU-6859a0.78
8084 + 868CPFX50–100
LVFX12.5–25
DU-6859a0.78–1.56
8084 + 883CPFX50–800
LVFX12.5–50
DU-6859a0.78–3.13
84844CPFX100–800
LVFX25–100
DU-6859a1.56–6.25
8484 + 881CPFX800
LVFX400
DU-6859a50
80 + 848441CPFX100–>800800800
LVFX25–10050100
DU-6859a0.78–6.256.256.25
80 + 8473 + 841CPFX200
LVFX50
DU-6859a1.56
80 + 8484 + 856CPFX≧800
LVFX≧800
DU-6859a25
80 + 8484 + 861CPFX200
LVFX50
DU-6859a3.13
80 + 81881CPFX100
LVFX12.5
DU-6859a0.78
81 + 84841CPFX200
LVFX50
DU-6859a3.13
77 (silent)7CPFX0.2–1.56
LVFX0.2–0.39
DU-6859a0.025–0.05
100 (silent)4CPFX0.39
LVFX0.2
DU-6859a0.025–0.05
86 (silent)8CPFX0.39–3.13
LVFX0.2–0.78
DU-6859a0.025–0.1
132CPFX0.2–3.130.781.56
LVFX0.1–0.780.390.39
DU-6859a0.013–0.10.050.05