Table 3.

Nucleotide sequences of blaTEM-47,blaTEM-48, and blaTEM-49genes compared with those of blaTEM-1a,blaTEM-1b, blaTEM-2, and some blaTEM-2-related genes

Nucleotidea (amino acidb) positionNucleotide (amino acid)c
blaTEM-1adblaTEM-1beblaTEM-2eblaTEM-4fblaTEM-9gblaTEM-25hblaTEM-48blaTEM-49blaTEM-47
226CTT
263 (21)C (Leu)T (Phe)T (Phe)T (Phe)T (Phe)T (Phe)
317 (39)C (Gln)A (Lys)
346AGGGGGG
436CTTTTTTTT
512 (104)G (Glu)A (Lys)A (Lys)
604GT
682TCCCCCCC
692 (164)C (Arg)A (Ser)
914 (238)G (Gly)A (Ser)A (Ser)A (Ser)A (Ser)A (Ser)
917 (240)G (Glu)A (Lys)A (Lys)A (Lys)
925GAAAAAAA
990 (265)C (Thr)T (Met)T (Met)T (Met)T (Met)T (Met)T (Met)
998 (268)A (Ser)G (Gly)
  • a Nucleotide positions are numbered according to Sutcliffe (38).

  • b Amino acid positions are numbered according to Ambler et al. (1). Amino acid numbers are indicated only for positions in which substitutions are observed.

  • c Only mutational changes with respect to the TEM-1 β-lactamase and/or blaTEM-1a gene sequences are listed.

  • d Data are from a previous report (38).

  • e Data are from previous reports (16, 17).

  • f Data are from a previous report (37).

  • g Data are from a previous report (28).

  • h Data are from a previous report (15).