Table 3.

Effect of MPA on the anti-VZV (wild-type and TK strains) activities of ACV and GCV

Virus strainAntiviral agentEC50(μg/ml)a
GCV aloneACV aloneWith MPA at 10 μg/mlWith MPA at 2.5 μg/mlWith MPA at 1.0 μg/ml
OKA (TK+)GCV0.86 ± 0.890.09 ± 0.090.11 ± 0.120.11 ± 0.12
ACV0.45 ± 0.070.06 ± 0.040.05 ± 0.030.08 ± 0.02
YS-R (TK)GCV27 ± 311.5 ± 1.11.6 ± 1.01.4 ± 1.4
ACV27 ± 200.8 ± 0.61.5 ± 0.70.55 ± 0.07
  • a Data are mean values for two separate experiments. The EC50 of MPA alone is >10 μg/ml.