Table 5.

Summary of resistance mechanisms observed in sequential yeast isolates from AIDS patients

Patient no.C. albicans isolateRelative (fold) increase in MIC of:Resistance mechanism(s) linked to MIC increase
FluconazoleKetoconazoleItraconazole
IC23111S405F mutation on one allele
C393282S405F mutation on two alleles; increase in CDR1 and CDR2 mRNAs
IIIC33111
C34812S405F mutation
C821283232Increase in CDR1and CDR2 mRNAs
C2651225664Y132H mutation
IVC27111
C37822G464S and R467K mutations
C4012812832Y132H mutation on one allele; increase in BENr mRNA
VC43111
C5651225664G129A and G464S mutations
Increase in CDR1and CDR2 mRNAs