Table 5.

Effect of exogenously added guanosine on the potentiating effect of MPA on the anti-HSV-1 activity of ACV, GCV, or PCV in Vero cells

Anti- viral agentEC50(μg/ml)a
GCV aloneACV alonePCV aloneWith MPA at 1.0 μg/mlWith MPA at 1.0 μg/ml + guanosine at 25 μg/ml
GCV0.49 ± 0.190.015 ± 0.0070.64 ± 0.07
ACV4.15 ± 4.00.09 ± 0.061.2 ± 0.2
PCV2.9 ± 0.30.14 ± 0.03.15 ± 0.6
  • a The EC50s for inhibition of HSV-1-induced CPE by MPA and guanosine were >25 μg/ml and >100 μg/ml, respectively.