Table 7.

Pharmacodynamic model goodness of fit

Antimicrobial exposure (AUC0–24/MIC)an% Observed resistance% Modelled fits
<1001782.482.6
≥100979.39.2
0–50875.082.6
50–100988.980.9
100–2502114.310.2
250–500166.39.2
500–1,0001822.29.2
>1,000422.49.2
BLAC, all1464.364.3
BLAC, 100–250110083.2
BLAC, 250–500366.776.6
BLAC, 500–1,000475.072.3
BLAC, >1,000650.049.6
  • a BLAC, type I β-lactamase-producing organisms treated with β-lactam monotherapy. The numbers following BLAC indicate the AUC0–24/MIC ranges; all, all AUC0–24/MIC values.