TABLE 3.

Selecteda drug-relatedb clinical adverse experiences

SymptomCaspofungin acetatecAmphotericin B, 0.5 mg/kg (n = 35)
35 mg (n = 34)50 mg (n = 34)70 mg (n = 37)
n (%)n (%)n (%)n (%)
Chills1 (2.9)**1 (2.9)**1 (2.7)**28 (80.0)
Fever7 (20.6)**4 (11.8)**6 (16.2)**25 (71.4)
Phlebitis3 (8.8)1 (2.9)2 (5.4)5 (14.3)
Diarrhea1 (2.9)0 (0.0)1 (2.7)5 (14.3)
Nausea3 (8.8)*1 (2.9)**1 (2.7)**11 (31.4)
Vomiting0 (0.0)**0 (0.0)**1 (2.7)*8 (22.9)
Rash3 (8.8)0 (0.0)0 (0.0)1 (2.9)
Headache4 (11.8)2 (5.9)2 (5.4)*8 (22.9)
  • a Specific adverse events occurring in ≥7.5% of patients in any treatment group.

  • b Determined by the investigator to be possibly, probably, or definitely drug related.

  • c ∗, P ≤ 0.05 versus amphotericin B; ∗∗, P ≤ 0.01 versus amphotericin B.