TABLE 2

Comparison of the activity of TAC, D6, D15, and D17 against clinical isolates from CF and non-CF patients

StrainMorphotypeSource (reference)MIC (μg/ml) fora:
D6D15D17TACAMK
M. abscessus
    CIP104536RNon-CFb (25)12.53.16.220012.5
    2524RCF6.23.16.210025
    2648RCF6.21.63.110012.5
    3022RNon-CF3.10.81.610012.5
    CFRCF3.11.63.110012.5
    CIP104536SNon-CFb (25)256.225>20025
    3321SNon-CF6.21.66.2520025
    1298SCF256.225>20012.5
    2587SCF12.53.112.520025
    2069SNon-CF12.56.212.510025
    CFSCF12.53.16.220012.5
M. massiliense
    CIP108297RAddison disease (26)6.23.13.110012.5
    210RCF3.10.41.610012.5
    CIP108297SAddison disease (26)12.51.63.1>20025
    111SCF6.23.16.220025
    212SCF12.53.112.5>20025
    185SCF12.53.16.220025
    140SCF6.23.16.220025
    100SCF6.21.66.2200>100
    107SCF12.53.16.2>20012.5
    122SCF3.11.61.610012.5
    120SCF12.53.16.2>20012.5
M. bolletii
    19RNon-CF6.21.63.110050
    108RCF3.10.40.810012.8
    112RCF3.16.212.5200>100
    CIP108541SNot reportedb12.53.16.210025
    17SNon-CF12.51.66.220012.5
    97SCF6.20.83.120012.5
    114SCF12.56.212.520012.5
    116SCF3.10.41.620012.5
  • a The MIC was determined in cation-adjusted Mueller-Hinton broth for different subspecies belonging to the M. abscessus complex. AMK, amikacin.

  • b Seed stock of ATCC 19977T, isolated from a knee abscess.