TABLE 1.

Baseline patient characteristics by treatment group

CharacteristicValue for patients exhibiting characteristicaTotal patients (n = 140)
Caspofungin acetate, 35 mg (n = 34)Caspofungin acetate, 50 mg (n = 34)Caspofungin acetate, 70 mg (n = 37)Amphotericin B, 0.5 mg/kg (n = 35)
Stratumb
    Esophageal (± oropharyngeal)21 (61.8)20 (58.8)24 (64.9)23 (65.7)88 (62.9)
    Oropharyngeal (exclusively)13 (38.2)14 (41.2)13 (35.1)12 (34.3)52 (37.1)
Substratumc
    Unresponsive to fluconazole6 (17.6)3 (8.8)7 (18.9)5 (14.3)21 (15.0)
    Responsive to fluconazoled28 (82.4)31 (91.2)30 (81.1)30 (85.7)119 (85.0)
Stratum-substratume
    12 (5.9)1 (2.9)2 (5.4)1 (2.9)6 (4.3)
    211 (32.4)13 (38.2)11 (29.7)11 (31.4)46 (32.9)
    34 (11.8)2 (5.9)5 (13.5)4 (11.4)15 (10.7)
    417 (50.0)18 (52.9)19 (51.4)19 (54.3)73 (52.1)
HIV infection
    Positive32 (94.1)33 (97.1)37 (100.0)35 (100.0)137 (97.9)
    Negative2 (5.9)1 (2.9)0 (0.0)0 (0.0)3 (2.1)
Baseline esophageal grade
    1/21 (2.9)2 (5.9)2 (5.4)3 (8.6)8 (5.7)
    14 (11.8)0 (0.0)2 (5.4)1 (2.9)7 (5.0)
    23 (8.8)5 (14.7)7 (18.9)3 (8.6)18 (12.9)
    310 (29.4)11 (32.4)9 (24.3)12 (34.3)42 (30.0)
    42 (5.9)2 (5.9)4 (10.8)4 (11.4)12 (8.6)
Baseline oropharyngeal grade
    16 (17.6)6 (17.6)2 (5.4)4 (11.4)18 (12.9)
    23 (8.8)8 (23.5)7 (18.9)4 (11.4)22 (15.7)
    34 (11.8)0 (0.0)4 (10.8)4 (11.4)12 (8.6)
CD4 countf
    No. of patients31323634133
    Mean109.272.651.959.472.2
    SD198.199.8102.465.9124.9
    Median48.034.021.529.030.0
    Range2-8790-4050-5610-2600-879
  • a Results are presented as number (percent) unless otherwise indicated.

  • b Primary site of infection.

  • c Prior response to fluconazole.

  • d Includes patients not previously exposed to fluconazole or other azole antifungal agents.

  • e Stratum-substratum categories: 1, oropharyngeal candidiasis alone and unresponsive to fluconazole; 2, oropharyngeal candidiasis alone and responsive to or not previously exposed to fluconazole; 3, esophageal candidiasis (with or without oropharyngeal candidiasis) and unresponsive to fluconazole; 4, esophageal candidiasis (with or without oropharyngeal candidiasis) and responsive or not previously exposed to fluconazole.

  • f CD4 count tabulations include only those patients with HIV infection. Mean, standard deviation, median, and range are given as number of cells per cubic millimeter.