Table 2.

FKBP12 and TOR mutations confer resistance to rapamycin and analogsa

StrainaMICs and MFCs (μg/ml)b of:
RapamycinAnalog
2181923
MICMFCMICMFCMICMFCMICMFCMICMFC
C. neoformansWT0.190.393.123.12>100>100>100>1001.563.12
C. neoformans frr1 >100>100>100>100>100>100>100>100>100>100
C. neoformans TOR1-1 >100>100>100>100>100>100>100>100>100>100
C. albicansWT<0.090.396.2512.5>100>100>100>1000.780.78
C. albicans rbp1/rbp1 >100>100>100>100>100>100>100>100>100>100
C. albicans TOR1-1/TOR1 >100>100>100>100>100>100>100>100>100>100
  • a WT, wild type.

  • b Drug dilutions were from 100 to 0.09 μg/ml.