Table 1.

Steady-state pharmacokinetic parameters for TMP, SMX, andN-acetyl-SMX after administration of 160/800 mg of co-trimoxazole alone or with 600 mg of rifampina

Drug and administrationCmax(μg/ml)Tmax (h)AUC (μg  ·  h/ml)ΔAUC (%)
TMP
 Alone2.01 (1.07 to 12.99)2 (1.5 to 6)22.4 (13.5 to 65.2)
 With rifampin1.13 (0.70 to 1.94)2 (1 to 4)9.8 (7.0 to 17.7)−46.7 (−84.9 to +5.1)
P 0.170.0880.013
SMX
 Alone42.1 (30.2 to 55.7)2 (1.5 to 4)574.2 (342.6 to 796.3)
 With rifampin41.5 (24.8 to 66.4)2.5 (1 to 4)412.4 (273.0 to 930.2)−22.7 (−29.3 to +22.9)
P 0.720.670.047
N-Acetyl-SMX
 Alone8.7 (5.8 to 25.4)4 (1 to 6)146.3 (63.3 to 485.2)
 With rifampin8.4 (4.2 to 21.4)5 (1.5 to 12)152.8 (57.8 to 390.5)+12.2 (−48.9 to +80.1)
P 0.570.140.79
Metabolite/parent ratio
 Alone0.29 (0.09 to 1.15)
 With rifampin0.38 (0.14 to 1.18)+31.6 (−14.1 to +164.0)
P
  • a The values shown are medians (ranges) (n = 10) .