TABLE 3.

Correlation of specific mutations with rifampin MICsa

StrainRifampin MIC (μg/ml)MutationMutation typeAmino acid change
ICC22110G1317ANovelL521L
ICC208, ICC20510A1304TReportedD516V
ICC3710A1304GReportedD516G
ICC20440G1317ANovelL521L
ICC20440G1336TNovelK527N
ICC10540G1336TNovelK527N
ICC12940G1338CNovelR528P
ICC13140C1331TReportedH526Y
ICC13140G1338CNovelR528P
ICC12364G1338CNovelR528P
ICC10064C1349TReportedS531L
ICC21364G1340ANovelR528H
ICC21364C1349GReportedS531W
ICC21864T1321CNovelS522Q
ICC21864C1322ANovelS522Q
ICC25764G1287TNovelQ510H
ICC25764C1288TNovelL511L
ICC27564C1333TReportedH526Y
ICC22064C1349GReportedS531W
ICC128128C1331TReportedH526Y
ICC128128G1338ANovelR528H
  • a Missense mutations in the RpoB protein at amino acid positions 510, 511, 522, 526, 527, 528, and 531 confer higher levels of resistance (MICs, ≥40 μg/ml) than those at positions 509, 516, and 521 (MICs, ≤10 μg/ml).