Table 1.

Effects of 0.5 and 1.0 μg of azithromycin per ml on infectious chlamydial progeny in HEp-2 cellsa

Day after infectionMean no. of IFU/105 cells
0.5 μg/ml1.0 μg/ml
267,672 ± 9,59967,672 ± 9,599
424,307 ± 12,44112,871 ± 2,372
6344 ± 202241 ± 156
88 0
100 0
  • a HEp-2 cells were infected at a MOI of 0.05. Incubation with azithromycin was started 2 days postinfection. Culture of cells without antibiotics resulted in complete destruction of the cell monolayer in 6 days. The data are the mean numbers of IFU per 105 cells determined in five and four experiments with concentrations of 0.5 and 1.0 μg/ml, respectively.