TABLE 4.

Combinations of antibiotics demonstrating enhanced activity against carbapenem-resistant A. baumannii

Study typeAntibiotic combination (reference[s])
In vitroMeropenem + ampicillin-sulbactam (90, 92)
Imipenem + ampicillin-sulbactam (26)
Rifampin + ampicillin-sulbactam (197)
Rifampin + polymyxin B (197, 230)
Rifampin + colistin (69)
Imipenem + polymyxin B + rifampin (230)
Imipenem + polymyxin B (230)
Cefepime + ampicillin-sulbactam (173)
Animal modelsMeropenem + ampicillin-sulbactam (92)
Imipenem + ampicillin-sulbactam (226)
Imipenem + tobramycin (124)
Imipenem + rifampin (124, 226)
Rifampin + tobramycin or colistin (124)
Rifampin + ampicillin-sulbactam (226)
Clinical experienceRifampin + colistin (126, 146)
Colistin + othersa (88, 189)
  • a Imipenem, meropenem, ampicillin-sulbactam, piperacillin-tazobactam, cefepime, quinolones, and aminoglycosides.