TABLE 2.

Results of secondary screening with antiviral hit compounds from the SM and BUCMLD librariesa

Compound nameEC50CC50
BUCMLD-B10A11<0.5 (<0.5-0.5)19.5 (19.4-22.4)
BUCMLD-B10A30.7 (<0.5-5.2)9.0 (7.1-10.0)
BUCMLD-XL-1841.4 (0.8-3.9)>50
BUCMLD-B10A51.5 (<0.5-5.4)39.3 (28.6->50)
BUCMLD-XL-1902.5 (<0.5-10)>50
BUCMLD-B10A12.6 (1.0-5.0)18.0 (15.9-19.5)
SM_A14B53.5 (2.7-4.4)27.1 (18.0-44.6)
BUCMLD-XL-1893.8 (2.2-7.0)>50
SM_A6B5_2P1006.6 (4.0-15.3)>50
BUCMLD-B10A87.0 (0.9-30.0)>50
BUCMLD-B10A107.0 (5.4-30.0)>50
BUCMLD-B10A147.6 (1.0-23.0)>50
BUCMLD-B10A77.75 (1.0-30.0)35.3 (33.6-36.7)
SM_A4B6_2P1238.0 (6.3-10.0)>50
SM_A5B5_2P1189.1 (2.5-16.7)>50
SM_A7C2_2P15512.7 (7.0-24.0)>50
BUCMLD-B13A214.2 (6.4-45.0)>50
SM_A1B2_1P3219.6 (11.7-28.2)>50
SM_A1B5_2P2419.7 (6.25-50.0)>50
BUCMLD-B13A121.1 (7.5-36.7)>50
SM_A5B3_2P14125.7 (18.3-39.8)>50
SM_A5B2_2P14226.7 (9.1-50.0)>50
BUCMLD-NTM-EN2-67A30.0 (0.7-46.1)>50
SM_A12B3>30>50
BUCMLD-B10A1342.9 (25.2-59.4)>50
BUCMLD-XL-130>100>50
  • a Note that structure-activity relationship SM library compounds are also included. The EC50 and 50% cytotoxic concentration (CC50) are reported in μM with 95% confidence intervals in parentheses. A value of <0.5 indicates a concentration of less than 0.5 μM; >30 indicates a concentration of greater than 30 μM; >50 indicates a concentration of greater than 50 μM; and >100 indicates a concentration of greater than 100 μM.