TABLE 2.

Noncompartmental pharmacokinetic parameters for ZDV and 3TC metabolites in subjects receiving 600 mg of ZDV and 300 mg of 3TC QD (n = 27)

ParameterZDV-MPZDV-DPZDV-TP3TC-MP3TC-DP3TC-TP
Median Cmax (fmol/106 cells)2,997.6562.4743.907604,4244,840
Median Cmin (fmol/106 cells)38.827.956.262491,0551,002
Median Tmax (h)244664
Mean Tmax (h)2.443.484.746.306.376.67
Median AUC tra11,88362750210.4270.0165.19
Mean half-life (h) ± SEM9.1 ± 0.8517.7 ± 2.8
  • a ZDV metabolite AUCs were calculated in femtomoles, and 3TC metabolite AUCs were calculated in picomoles.