TABLE 1.

GM MICs and ranges of MICs (mg/liter) obtained at 24 and 48 h for azole drug-susceptible and -resistant A. fumigatus isolates

AntifungalReading time (h)GM MIC (range) for:
Susceptible isolates (n = 150)Resistant isolates (n = 33)
Amphotericin B240.14 (0.03-1)0.14 (0.06-0.5)
480.30 (0.12-2)0.29 (0.06-1)
Itraconazole240.16 (0.06-0.5)5.11 (0.25-16)
480.33 (0.12-1)16 (16-16)
Voriconazole240.29 (0.03-1)0.81 (0.12-8)
480.56 (0.06-2)1.6 (0.12-8)
Ravuconazole240.32 (0.06-1)1.13 (0.12-8)
480.60 (0.12-2)2.4 (0.12-16)
Posaconazole240.04 (0.015-0.12)0.41 (0.06-16)
480.08 (0.03-0.5)0.83 (0.25-16)