TABLE 1.

Activities of BAL19403 and ERY

StrainResistance mechanismERYBAL19403
MIC (μg/ml)IC50 (μM)Kd (nM)MIC (μg/ml)aIC50 (μM)Kd (nM)
E. coli BL21Outer membrane1280.76 ± 0.04111 ± 3.81280.42 ± 0.07226 ± 6.2
P. acnes EG7NS≤0.060.17 ± 0.009629 ± 15≤0.060.11 ± 0.012
P. acnes P95G2057A42.2 ± 0.14>2,100≤0.060.12 ± 0.0054
P. acnes SW54EAA2058G>51287 ± 130.50.26 ± 0.0050
P. acnes GE4EErm(X)>5121.9 ± 0.62 and >500≥2560.19 ± 0.014 and >50
  • a MICs for P. acnes strains are taken from reference 16.