TABLE 2

Interactions of amphotericin B-rifampin combinations against ocular Fusarium solani species complex and Aspergillus flavus species complex isolates

CombinationFICI and % of isolates showing interactiona
Fusarium solani species complex (n = 51)Aspergillus flavus species complex (n = 44)
FICI (mean ± SD)SynergyIndifferenceFICI (mean ± SD)SynergyIndifference
AMB-RIF(4)b0.58 ± 0.2411.888.20.61 ± 0.2713.686.4
AMB-RIF(8)c0.38 ± 0.1951.049.00.42 ± 0.2145.554.5
AMB-RIF(16)d0.23 ± 0.1990.29.80.19 ± 0.2093.26.8
AMB-RIF(32)e0.19 ± 0.1194.15.90.17 ± 0.2095.54.5
  • a Interactions: synergy, FICI of ≤0.5; indifference, FICI of >0.5 and ≤4; antagonism, FICI of >4.

  • b Amphotericin B at 10 concentrations in combination with 4 μg/ml rifampin.

  • c Amphotericin B at 10 concentrations in combination with 8 μg/ml rifampin.

  • d Amphotericin B at 10 concentrations in combination with 16 μg/ml rifampin.

  • e Amphotericin B at 10 concentrations in combination with 32 μg/ml rifampin.