TABLE 2

Change in CFU over 72 h

RegimenaChange in log10 CFU/g from 0 to 72 h for strainb:
W04W07W151
CRO−0.720.08−0.52
CPT−2.31−0.08−0.75
AMP−3.8−3.15−2.76
AMP + CRO−4.65*−3.58−5.66*
AMP + CPT−5.05*−4.16*−5.34*
  • a CRO, simulations of 2 g ceftriaxone intravenously every 12 h; CPT, 600 mg ceftaroline intravenously every 8 h; AMP, 2 g ampicillin intravenously every 4 h.

  • b Symbols: *, significantly greater log10 CFU/g reduction than with AMP (P ≤ 0.05); §, significantly greater log10 CFU/g reduction than with AMP + CRO alone (P ≤ 0.05).