TABLE 5

Comparisons of 30-day mortality rates after CRE bacteremia by a definitive antimicrobial regimen

Definitive antimicrobial regimen30-day mortality rate (%)
Monotherapya (n = 55)38
    Polymyxin (n = 25)40
        Polymyxin B (n = 18)39
        Colistin (n = 7)43
    Tigecycline (n = 17)39
    Aminoglycoside (n = 11)43
    With a carbapenem (n = 22)50
    Without a carbapenem (n = 33)30
Combination therapyb (n = 43)
    Polymyxin-tigecycline (n = 18)56
    Aminoglycoside-tigecycline (n = 9)33
    With a carbapenem (n = 16)62
    Without a carbapenem (n = 27)44
Regimens with carbapenems (n = 38)55
Regimens without carbapenems (n = 60)37
  • a Use of only one active antimicrobial agent (an agent to which the CRE tested susceptible in vitro).

  • b Use of at least two active antimicrobial agents.