TABLE 1

In vitro susceptibilities of ocular Fusarium solani species complex and Aspergillus flavus species complex isolates to amphotericin B and rifampin alone and in combination

Organism (no. of isolates) or agentaMIC (μg/ml)
RangeMIC50MIC90
Fusarium solani species complex (51)
    AMB0.5–1624
    RIF4,0964,0964,096
    AMB-RIF(4)b0.25–412
    AMB-RIF(8)c0.125–20.52
    AMB-RIF(16)d0.063–10.250.5
    AMB-RIF(32)e0.063–10.250.5
Aspergillus flavus species complex (44)
    AMB1–3224
    RIF4,0964,0964,096
    AMB-RIF(4)b0.5–412
    AMB-RIF(8)c0.125–212
    AMB-RIF(16)d0.063–10.250.5
    AMB-RIF(32)e0.031–10.250.5
  • a AMB, amphotericin B; RIF, rifampin.

  • b Amphotericin B at 10 concentrations in combination with 4 μg/ml rifampin.

  • c Amphotericin B at 10 concentrations in combination with 8 μg/ml rifampin.

  • d Amphotericin B at 10 concentrations in combination with 16 μg/ml rifampin.

  • e Amphotericin B at 10 concentrations in combination with 32 μg/ml rifampin.