TABLE 5

MICs of D6, D15, D17, and amikacin against MmpS5/MmpL5-overexpressing strains

StrainaMIC (μg/ml) forb:
D6D15D17AMK
CIP104536 S
    Wild type2512.512.525
    pMV261_mmpS5/mmpL5>200>200>20025
CIP104536 R
    Wild type12.53.16.2525
    pMV261_mmpS5/mmpL5>200>200>20012.5
  • a M. abscessus S and R strains were transformed with pMV261_mmpS5/mmpL5.

  • b The MICs were determined in cation-adjusted Mueller-Hinton broth. Data are representative of two independent experiments. AMK, amikacin.