Table 4.

Summary data for patients shedding ACV-resistant virusa

Immune statusPatient no.Disease statusIsolation siteVirus typePhenotypeIC50 (μM)Treatment historyDose
Immunocompetent1GenitalGenital2UC12None
2GenitalGenital2TKD 18ACV cream
3GenitalGenital2TKA 5.5None
4GenitalGenital2UC19None
5KeratitisEye2TKD 110No information
Immunocompromised6HIV positiveGenital1TKD 22Prophylaxis (oral)400 mg BID
7Lung transplantLung1TKD 43Prophylaxis (oral)200 mg BID
8AMLOral1TKD 19Treatment (oral)Not known
9BMTOral1TKA 40Treatment (oral)200 mg QID
10BMTOral1TKD 11Prophylaxis (oral)200 mg 5× daily
11Heart transplantOral1TKD 3Treatment (oral)b 200 mg TID
  • a Abbreviations: UC, uncharacterized phenotype; BID, twice daily; QID, four times daily; TID, three times daily; AML, acute myelocytic leukemia; BMT, bone marrow transplant.

  • b This patient also received ganciclovir.