Table 4.

Efficacy of amphotericin B compared with that of LY303366 in reducing tissue colony counts for mice infected with A. fumigatus AF210 or AF65a

TreatmentP value for difference in reducing CFU ofb:
AF210AF65
LY 1LY 2.5LY 10LY 25LY 1LY 2.5LY 10LY 25
LungKidneyLungKidneyLungKidneyLungKidneyLungKidneyLungKidneyLungKidneyLungKidney
AB 0.50.730.680.02*0.01*0.008*0.003*0.02*0.01*0.430.340.210.560.390.470.240.38
AB 20.090.01#0.790.340.850.230.850.220.210.780.01*0.02*0.04*0.02*0.03*0.009*
AB 5/40.002#0.0001#0.210.01#0.090.003#0.210.004#0.390.550.080.140.210.110.120.11
AB 50.03#0.004#0.970.03#0.970.02#0.970.01#0.240.660.080.01*0.02*0.01*0.02*0.003*
  • a LY 1, LY 2.5, LY 10, and LY 25, LY303366 at 1, 2.5, 10, and 25 mg/kg/day, respectively; AB 0.5, AB 2, and AB 5, amphotericin B at 0.5, 2, and 5 mg/kg/day, respectively; AB 5/4, amphotericin B at 5 mg/kg, given in four doses.

  • b *, Treatment with LY303366 was superior; #, treatment with amphotericin B was superior.