Table 3.

Culture results for lungs and kidneys of mice infected with A. fumigatus AF210 and AF65

TreatmentaAF210AF65
No. of survivors/total no. of miceMean CFU (102)b in:No. of survivors/total no. of miceMean CFU (102)b in:
LungsKidneysLungsKidneys
i.p. control0/103.1 (0)330 (0)1/1016.1 (7.8)344 (171.8)
i.v. control0/103.1 (0)330 (0)0/1020 (0)430 (0)
AB (mg/kg)
 0.5/day1/102.8 (0.9)297 (97.8)4/1012.2 (9.5)269 (198.7)
 2/day7/100.9 (1.4)**101 (149.7)**1/1018.0 (6.0)388 (126.0)
 5, in 4 doses10/100.6 (1.2)**  3.5 (4.3)**3/1014.1 (9.0)306 (189.3)
 5/day8/101.0 (1.3)** 66 (131.6)**1/1018.0 (5.9)419 (33.0)
LY (mg/kg/day)
 13/102.4 (1.2)271 (118.0)2/1016.1 (7.7)365 (130.0)
 2.57/100.9 (1.4)**109 (144.7)**8/10 4.6 (7.7)**182 (177.3)*
 108/100.6 (1.2)** 77 (126.4)**7/10 7.2 (8.8)**135 (192.6)*
 258/100.9 (1.4)**127 (139.3)**8/10 7.0 (8.9)**116 (164.1)*
  • a i.p., intraperitoneal; i.v., intravenous; AB, amphotericin B; LY, LY303366.

  • b Numbers in parentheses represent standard deviations. *, P < 0.05 (comparison with controls); **, P < 0.01 (comparison with controls).