Table 7.

Proposed amikacin dosing regimens to achieve first 1-h-peak level of >60 mg/liter in 90% of patients and trough (predose) level at steady state of <5 mg/liter in 95% of patients

CLCR (ml/min)Dose (mg/kg)Interval (h)
80–1302024
60–802236
40–602036
20–402048
10–201748