Proposed amikacin dosing regimens to achieve first 1-h-peak level of >60 mg/liter in 90% of patients and trough (predose) level at steady state of <5 mg/liter in 95% of patients
| CLCR (ml/min) | Dose (mg/kg) | Interval (h) |
|---|---|---|
| 80–130 | 20 | 24 |
| 60–80 | 22 | 36 |
| 40–60 | 20 | 36 |
| 20–40 | 20 | 48 |
| 10–20 | 17 | 48 |