Table 5.

Derived values of population pharmacokinetic parameters for amikacin in neutropenic patientsa

ValueCL (liters/h)t1/2β(h)VSS (liter)
MenWomenMenWomen
Mean3.823.405.66.020.6
SD1.521.282.02.23.4
Median3.603.255.25.620.1
5 and 95b 2.0 and 6.51.8 and 5.72.9 and 9.23.2 and 10.015.8 and 26.4
  • a Based on data for 1,000 simulated individuals with the following covariate distributions: age = 51 ± 16 (N); body weight = 67 ± 13 kg (N);S CR = 85 ± 37 μmol (LN).

  • b 5 and 95, 5th and 95th percentiles of the distribution, respectively.