Table 5.

Derived values of population pharmacokinetic parameters for amikacin in neutropenic patients^a

Value	CL (liters/h)		t_1/2β(h)		V_SS (liter)
Value	Men	Women	Men	Women	V_SS (liter)
Mean	3.82	3.40	5.6	6.0	20.6
SD	1.52	1.28	2.0	2.2	3.4
Median	3.60	3.25	5.2	5.6	20.1
5 and 95^b	2.0 and 6.5	1.8 and 5.7	2.9 and 9.2	3.2 and 10.0	15.8 and 26.4

↵a Based on data for 1,000 simulated individuals with the following covariate distributions: age = 51 ± 16 (N); body weight = 67 ± 13 kg (N);S _CR = 85 ± 37 μmol (LN).
↵b 5 and 95, 5th and 95th percentiles of the distribution, respectively.