Table 2.

Experimental concentrations of amikacin given o.d. or b.i.d. to 57 neutropenic adults

DosageTimeaNo. of samplesConcn (mg/liter)
MeanMedianSDRange
First day of administration
 20 mg/kg o.d.P2375.466.728.943–170
T (24)242.11.02.80.5–14.5
 7.5 mg/kg b.i.d.P2336.030.414.819.4–66.0
T (12)294.73.83.91.0–17.0
All administrations
 20 mg/kg o.d.P4374.175.526.429–170
T (24)531.71.02.00.5–14.5
 7.5 mg/kg b.i.d.P5039.336.617.013.7–86.0
T (12)645.03.74.31.0–20.7
  • a P, one-hour peak levels (i.e., 0.5 h after the end of the infusion); T (24), 24-h trough levels; T (12), 12-h trough levels.