Table 2.

Survival times for mice infected with A. fumigatus AF210 or AF65 and treated with amphotericin B or LY303366

IsolateMedian survival time (days) and range for mice receiving the following treatmenta:
i.p. controli.v. controlAmphotericin BLY303366
0.5 mg/kg/day2 mg/kg/day5 mg/kg in 4 doses5 mg/kg/day1 mg/kg/day2.5 mg/kg/day10 mg/kg/day25 mg/kg/day
AF2103 (2–5)3 (2–3)5 (2–11)*11 (3–11)**,†11 (11)**,†11 (2–11)**,†5.5 (3–11)*11 (4–11)**11 (5–11)**11 (3–11)**
AF653.5 (3–11)3 (3–4)4 (3–11) 4 (3–11) 3 (3–11) 3 (3–11)5 (3–11)11 (6–11)**,‡11 (3–11)**,‡11 (7–11)**,‡
  • a i.p., intraperitoneal; i.v., intravenous; *, P < 0.05 (compared with controls); **,P < 0.01 (compared with controls); †,P < 0.05 (compared with AF65); ‡, P< 0.05 (compared with amphotericin B treatment of AF65).