TABLE 1

Pharmacokinetic parameters of ciprofloxacin and amikacin in the plasma and ELF in normal rats and rats with pulmonary fibrosis

ParameterCiprofloxacinAmikacin
Normal ratsRats with pulmonary fibrosisNormal ratsRats with pulmonary fibrosis
t1/2 (h)
    Plasma2.131.734.075.29
    ELF0.951.081.140.41
Cmax (mg/liter)
    Plasma22.0517.8598.5398.89
    ELF15.8014.0121.3314.41
AUC0–24 (h · mg/liter)
    Plasma25.4825.2478.8287.68
    ELF25.9219.2638.2423.64
Clearance (liters/h/kg)
    Plasma2.342.350.630.57
    ELF2.212.841.212.11