Table 2.

Correlation of inhibition of photoaffinity labeling with biological activities of echinocandins

Compounda% InhibitionbMIC (μg/ml)cIC50(μg/ml)d
LY12101939.00.311.30
LY28094954.20.041.00
LY30336684.70.00250.70
  • a Semisynthetic echinocandins (see Fig.1).

  • b Inhibition of photoaffinity labeling of the 40-kDa protein (see Fig. 3).

  • c In Bacto Antibiotic Assay Medium 3.

  • d Glucan synthase IC50.