Table 1.

Pharmacodynamic variables for five total doses of fluconazole administered in one, two, or four equally divided doses

Total fluconazole dosage (mg/kg/24 h)Regimen (no. of doses)aCmax/MIC ratiobAUC/MIC ratioTime > MIC/24 h
3.53.5 mg/kg (one)11.034.879.1
1.75 mg/kg q 12 h (two)5.635.9913.4
0.875 mg/kg q 6 h (four)2.634.2317.2
4.04.0 mg/kg (one)12.540.379.3
2.0 mg/kg q 12 h (two)6.439.8113.8
1.0 mg/kg q 6 h (four)3.240.9818.0
4.54.5 mg/kg (one)14.045.149.94
2.25 mg/kg q 12 h (two)7.044.6315.08
1.125 mg/kg q 6 h (four)3.644.9720.26
5.05.0 mg/kg (one)15.649.4810.60
2.5 mg/kg q 12 h (two)7.247.8315.44
1.25 mg/kg q 6 h (four)3.450.0220.80
5.55.5 mg/kg (one)17.255.0211.27
2.75 mg/kg q 12 h (two)8.554.8816.54
1.38 mg/kg q 6 h (four)4.454.9321.58
  • a The first dose was administered 5 h after infection. q 6 h and q 12 h, every 6 and 12 h, respectively.

  • b The MIC for C. albicans ATCC 36082 was 0.5 μg/ml by the macrobroth dilution method of the National Committee for Clinical Laboratory Standards.