Table 2.

Fungal densities in kidneys of mice treated with various total doses of fluconazole administered in one, two, or four divided doses

Total fluconazole dose (mg/kg)Fungal density (mean ± 1 SD log10CFU/g) for the following schedule of administration:Pvaluea
One doseTwo divided dosesbFour divided dosesc
3.55.79 ± 0.125.78 ± 0.115.79 ± 0.120.68
4.05.70 ± 0.115.69 ± 0.105.71 ± 0.100.59
4.55.64 ± 0.155.56 ± 0.275.62 ± 0.180.34
5.05.48 ± 0.215.44 ± 0.195.41 ± 0.110.46
5.55.46 ± 0.145.25 ± 0.105.43 ± 0.190.32
  • a By analysis of variance. A Pvalue of <0.05 was considered statistically significantly different.

  • b The doses were given 12 h apart.

  • c The doses were given 6 h apart.