Table 1.

In vitro activity of the new ketolides HMR 3004 and HMR 3647 compared with those of other macrolides, ofloxacin, tetracycline, amoxicillin, penicillin G, and tetracycline in Germany

S. pneumoniae resistance phenotypeaNo. of isolates testedAntimicrobial agentMIC (μg/ml)
MIC50MIC90Range
Pens Erys 169HMR 3004≤0.030.125≤0.03–0.125
HMR 3647≤0.030.06≤0.03–0.125
Erythromycin A0.1250.50.06–0.5
Azithromycin0.060.125≤0.03–0.25
Roxithromycin0.2510.125–2
Clarithromycin0.1250.25≤0.03–0.5
Josamycin0.510.125–2
Ofloxacin240.5–8
Tetracycline0.2580.06–≥32
Amoxicillin0.0160.016≤0.008–0.06
Penicillin G0.0160.016≤0.008–0.03
PensEryi/Eryr 20HMR 30040.060.25≤0.03–0.5
HMR 36470.060.25≤0.03–0.5
Erythromycin A≥32≥321–≥32
Azithromycin16≥320.06–≥32
Roxithromycin≥32≥320.125–≥32
Clarithromycin8≥320.06–≥32
Josamycin1≥320.25–≥32
Clindamycin2≥320.06–≥32
Ofloxacin240.5–4
Tetracycline8≥320.125–≥32
Amoxicillin≤0.0080.016≤0.008–0.06
Penicillin G≤0.0080.016≤0.008–0.03
Peni Erys 24HMR 3004≤0.03≤0.03≤0.03
HMR 3647≤0.03≤0.03≤0.03–0.06
Erythromycin A0.1250.1250.06–0.25
Azithromycin0.1250.250.03–0.25
Roxithromycin0.250.50.25–0.5
Clarithromycin0.1250.250.06–0.25
Josamycin0.50.50.125–0.5
Ofloxacin242–≥16
Tetracycline4≥320.5–≥32
Amoxicillin0.2510.03–1
Penicillin G0.2510.125–1
PeniEryi/Eryr 8HMR 30040.062≤0.03–2
HMR 3647≤0.030.25≤0.03–0.25
Erythromycin A16≥328–≥32
Azithromycin16≥322–≥32
Roxithromycin16≥322–≥32
Clarithromycin8≥321–≥32
Josamycin1≥320.125–≥32
Clindamycin0.25≥320.125–≥32
Ofloxacin241–4
Tetracycline≥32≥320.25–≥32
Amoxicillin0.1250.50.06–1
Penicillin G0.2510.125–1
  • a Pens, penicillin susceptible (MIC ≤ 0.06 μg/ml); Erys, erythromycin susceptible (MIC ≤ 0.25 μg/ml); Peni, intermediate level of resistance to penicillin (MIC 0.125 to 1 μg/ml); Eryi/Eryr, intermediate level of resistance to erythromycin or erythromycin resistant (MIC ≥0.5 μg/ml).