Table 1.

Susceptibilities to and accumulation of NFX in four isogenic and four clinical K. pneumoniae strains

StrainPresence in strain ofa:NFX MIC (μg/ml)Accumulation of NFX (ng/mg [dry weight])b
O-AgK-AgOmpK34OmpK35OmpK36ControlCCCP
Isogenic strains
 C3O1K66+++0.015366 ± 65346 ± 46
 KT717O1+++0.03330 ± 67ND
 KT793+++0.03299 ± 68ND
 KT5003+0.06314 ± 54ND
Clinical strains
 LB2NDND++2286 ± 24385 ± 65
 LB4NDND+4116 ± 21263 ± 38
 CSUB10SNDND++4313 ± 6ND
 CSUB10RNDND+1666 ± 2076 ± 9
  • a OmpK34, OmpK35, and OmpK36 are theK. pneumoniae homologs of E. coli OmpA and porins OmpF and OmpC, respectively. O-Ag, O antigen; K-Ag, K antigen; ND, not determined.

  • b Data are means ± standard deviations of five experiments.