TABLE 2

Sterol composition of A. fumigatus treated with either posaconazole or PC945

SterolSterol content in cells (%)
DMSO-treated cellsPosaconazole-treated (μg/ml) cellsDMSO-treated cellsPC945-treated (μg/ml) cells
0.00010.0010.010.110.00010.0010.010.11
Ergosterol10094.587.274.767.867.410095.994.786.780.671.3
Ergost-5,7-dienol03.33.900004.12.53.300
Lanosterol003.07.08.88.80003.66.29.4
Eburicol02.25.918.323.423.8002.76.513.219.3