Table 5.

Cytotoxicity and selectivity of A-5021, ACV, and PCV in HEL and MRC-5 cells

Cell typeCompoundCD50(μg/ml)aSelectivity indexb
HSV-1 KOSHSV-2 186VZV Kawaguchi
HELA-5021371,60015055
ACV878715026
PCV29019011052
MRC-5A-5021292,600240110
ACV10037040083
PCV160230130230
  • a Values listed are the average results of two experiments.

  • b Ratio of the CD50 to the IC50 (Table 1) in each cell.