Table 1.

Characteristics of cefoxitin-resistant and -susceptible ESBL-producing K. pneumoniae pairs isolated from three patients and the transformed strains of CSUB10R containing plasmids coding for the entire (pSHA19) or truncated (pSHA20) sequence of OmpK36 porin

Antimicrobial agentMIC (μg/ml)
Patient 1CSUB10R(pSHA19)CSUB10R(pSHA20)Patient 2Patient 3
CSUB10RCSUB10SCSUB8RCSUB8SCSUB9RCSUB9S
Cefoxitin12820.612812841284
Cefotaxime>256432>256>256642564
Cefpirome>25628>25625681282
Ceftazidime>256>256>256>256>256>256>256>256
Ceftazidime-clavulanic acid20.50.524120.5
Aztreonam>256>256>256>256>256>256>256>256
Imipenem0.50.120.060.50.50.120.50.12
Meropenem20.060.12220.0320.03
Ofloxacin420.544284
Ciprofloxacin40.50.542122
Sparfloxacin410.2542121
Porin expression++++