Table 2.

ED50 of additive-free meglumine antimoniate for wild-type strain 1166 and SbV-resistant line selected in vitro and strains isolated from patients presenting relapse or reinfectiona

Expt no.StrainED50 (μg of SbV/ml)
1Internal control
 1166wt16.70
 1166SR140.22
Relapse
 RE-2407i>170.00
 RE-2407r85.90
2Internal control
 1166wt39.50
 1166SR209.94
Relapse
 RE-2025i>170.00
 RE-2025r>680.00
 RE-2238i>170.00
 RE-2238r170.00
3Internal control
 1166wt15.75
 1166SR209.50
Reinfection
 RI-2309iND
 RI-2309r97.19
 RI-2485i28.43
 RI-2485r132.40
  • a 1166 wt, wild-type 1166; 1166SR, strain 1166 selected for SbV resistance; i, strain isolated from initial lesion; r, strain isolated from recurrent lesion; ND, not determined.