Table 2.

Activities of ciprofloxacin and novobiocin against mutants of MT5

Mutant strainAmino acid mutation in GrlAMIC (μg/ml)
CiprofloxacinNovobiocin
MT50.2540.0
MT5224c4Ser80Phe2.040.0
MT52222Ser80Phe2.040.0
MT5224c2Ala116Pro2.020.0
MT52184Ala116Pro4.020.0
MT5224c3Ala116Glu2.020.0