Table 3.

Susceptibility patterns of S. aureus gyrB + strains diploid for grlA

Strain/plasmidgrlAa MIC (μg/ml)b
ChromosomePlasmidCiprofloxacinNorfloxacinNovobiocinCoumermycin
RN4220/pSK950WildNone0.51.00.160.02
RN4220/pBFMTAWildAla116Glu1.04.00.080.01
RN4220/pBFC2AWildAla116Pro1.04.00.040.01
RN4220/pBFC4AWildSer80Phe1.08.00.160.02
BF6/pSK950Ala116GluNone1.08.00.040.01
BF6/pBFISAAla116GluWild0.251.00.080.01
BF5/pSK950Ala116ProNone1.08.00.040.01
BF5/pBFISAAla116ProWild0.251.00.080.01
EN20/pSK950Ser80PheNone2.016.00.160.02
EN20/pBFISASer80PheWild0.251.00.160.01
  • a Wild, wild-type gene; none, plasmid vector only.

  • b The MICs are the mean values for at least three different transformants.