Table 4.

PAEs and PA-SMEs of imipenema

StrainPAE (h)PA-SME (h) of imipenem at the following multiples of the MIC:
0.1×0.2×0.3×0.4×0.5×
S. aureus ATCC 292311.3 (1.1–1.6)2.1 (2.0–2.3)3.2 (3.0–3.5)5.1 (4.7–5.5)8.3 (8.1–8.5)>14.8 (>14.8)
S. pneumoniae ATCC 63062.4 (2.1–2.7)3.1 (2.9–3.3)3.8 (3.4–4.1)5.2 (4.7–5.7)6.4 (5.7–7.0)7.6 (6.7–8.4)
H. influenzae NTCC 8468−0.5 (−1.4–0)6.4 (2.9–8.7)9.9 (8.7–10.7)>10.7 (>10.7)>10.7 (>10.7)>10.7 (>10.7)
E. coli ATCC 25922−0.9 (−0.8–−1.0)−0.2 (−1.0–−0.6)7.9 (7.1–8.1)13.9 (13.5–14.3)>15 (>15)>15 (>15)
E. cloacae EN 200.3 (0.2–0.4)0.5 (0.5–0.5)0.8 (0.7–0.8)1.8 (1.6–2.0)4.1 (3.8–4.4)6.2 (5.5–6.8)
  • a Values are means (ranges).