Table 2.

Pharmacokinetic parameters for meropenem

Patient no.Cmax(μg/ml)aCLtot(ml/min)CLHF (ml/min)kel(h−1)V(liters)t1/2 (h)AUC (mg/liter · h)
130.9128.759.30.2728.92.59129.5
227.5145.436.30.2930.12.39114.7
332.1162.851.40.4024.51.74102.4
424.8115.557.90.2330.13.00144.3
528.8163.141.80.3528.22.00102.2
627.3161.541.50.3131.02.22103.2
725.0163.644.30.2933.92.39101.9
825.1129.857.10.2333.92.46118.0
931.4122.757.40.2529.32.76135.9
Mean ± SD28.1 ± 2.5143.7 ± 18.649.7 ± 8.30.31 ± 0.0529.5 ± 2.72.33 ± 0.38118.0 ± 15.8
  • a Cmax, peak concentration of meropenem in plasma.