Table 4.

Amino acid substitutions in the OXY-2 β-lactamase group

EnzymeStrainpIAmino acid at the following positiona:
2035130197223255
OXY-2-1SL9115.2(Gly)b Asp Ser AspAlaAsp
OXY-2-2K17645.7Asn
OXY-2-3D4886.4AsnValAsn
OXY-2-411V6.8AlaAsnAsn
IRKO-1KER6.3(Ser) Gly AsnAsn
  • a Numbering is according to that given by Ambler et al. (1). Boldface indicates the amino acid substitution responsible for clavulanate resistance.

  • b Parentheses indicate signal peptide sequence.