Table 2.

PAEs and PA-SMEs of L-749,345a

StrainPAE (h)PA-SME (h) of L-749,345 at the following multiples of the MIC:
0.1×0.2×0.3×0.4×0.5×
S. aureus ATCC 292311.5 (1.4–1.6)2.0 (1.9–2.1)2.4 (2.3–2.6)2.9 (2.9–3.0)3.6 (3.4–4.1)4.2 (4.1–4.3)
S. pneumoniae ATCC 63062.4 (2.1–2.6)3.5 (3.0–3.9)4.3 (4.1–4.6)6.9 (5.4–9.0)>15.7 (>15.7)>15.7 (>15.7)
H. influenzae NTCC 84680 (0)1.8 (0.0–1.9)3.7 (3.1–4.0)6.9 (6.6–7.1)10.1 (9.6–10.7)11.7 (11.4–12.4)
E. coli ATCC 25922−0.3 (−0.1–−0.4)0.2 (0–0.3)0.6 (0.4–0.9)1.0 (0.9–1.3)1.6 (1.4–2.0)3.1 (2.3–3.6)
E. cloacae EN 200.3 (0–0.7)1.6 (1.4–2.0)3.3 (3.0–3.4)5.0 (4.0–6.4)6.5 (5.3–7.9)7.6 (5.3–9.0)
  • a Values are means (ranges).