Table 2.

Effect of sordarin derivatives on the cell-free protein synthesis assay (IC50s) and on cell growth (MICs)

CompoundC. albicans2005EC. glabrata2375EC. parapsilosis2372EC. krusei2374EC. neoformans2867EIC50 (μg/ml) for rabbit reticulocytes
IC50 (μg/ml)MIC (μg/ml)IC50(μg/ml)MIC (μg/ml)IC50 (μg/ml)MIC (μg/ml)IC50 (μg/ml)MIC (μg/ml)IC50 (μg/ml)MIC (μg/ml)
Sordarin0.018.00.2>125>100>125>100>1250.06>125>100
GR1354020.20.0150.8>125>100>125>100>1250.20.25>100
GM1605750.08<0.0010.4>125>100>125>100>1250.010.25>100
GM191519<0.0050.120.531.0100>125100>1250.005125>100
GM193663<0.005<0.0010.0231.0>100>125>100>1250.28.0>100
GM211676<0.0050.0010.018.0100>125100>1250.121.0>100